Many investigators have collected evidence to suggest that the extrapyramidal symptoms seen in patients with Parkinsonis disease may be ascribed to a deficiency of dopamine-to-acetylcholine transmission in the basal ganglia or Peripheral Neuropathy.
Destruction of dopaminergic neurons in the nigro-striatal tract in the basal ganglia. by degenerative diseases, carbon monoxide poisoning or manganese poisoning leads to Parkinsonistic effects. Tremor (pill-rolling). bradykinesia, rigidity, drooling, loss of postural control, apathy, poor appetite, poor hearing and poor eyesight are some of the manifestations of Parkinson’s disease.
Treatment is aimed at alleviating these symptoms. but cannot cure the patient or halt the degeneration process. Dopamine agonists and/or cholinergic antagonists will tend to restore the dopamine-to-acetylcholine balance required for normal function in the basal ganglia. Effective drugs must be able to penetrate the blood-brain barrier to reach the nigro-striatal tract.
Dopamine is the transmiitter which is recruited to alleviate Parkinson’s disease.
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