Find the supplies you need to create a custom frame or else to set and hang a picture that already has a frame. Find a supplier that offers a wide variety of resources for making custom frames and creating special hangers to create whatever effect is desired. A very special picture should hold to a wall in a special way.
An extreme example is a floating frame, where the frame is held away from the wall with clear or hidden pegs that attach to nails in the wall. The result is a three-dimensional appearance that helps to attract attention and might achieve a bolder effect. More standard wire or sheet metal hangers can help to steadily hold a picture to the wall. Find picture framing supplies that are an improvement over what cheaper frames might have come with. Upgrade your gallery.